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World Health Organization : Technical Report Series, No. 824: World Health Organization Technical Report Series, No. 824 ; World Health Organization Expert Committee on Rabies

By N. Haddad


Description
Medical Reference Publication

Excerpt
Introduction The WHO Expert Committee on Rabies met in Geneva from 24 to 30 September 1991. Opening the meeting on behalf of the Director-General, Dr R. Henderson, Assistant Director-General, pointed out that rabies continues to be a major health hazard in many countries in Africa, South America and Asia, and an economic burden for both developed and developing countries, in spite of recent advances in diagnosis, human post-exposure treatment, the production of vaccines for human and veterinary use and the control of rabies in dogs and wild animals.

Table of Contents
Contents I. Introduction 1 I .I Recent advances 1 1.2 Canine rabies 1 1.3 Laboratory techniques in rabies 1 2. Advances in rabies research 2 2.1 M ~ n ~ c l ~anntaiblo dies and the classification of rabies and rabies-related viruses 2 2.2 Molecular biology of the rabies virus 2 2.3 Molecular epidemiology 3 2.4 Research in vaccine development 4 2.4.1 Candidate vaccines 4 2.4.2 Safety aspects 5 2.5 New substances for post-exposure treatment and new post-exposure vaccination regimens 6 2.5.1 Monoclonal antibodies 6 2.5.2 Interferon and interferon-inducers 6 2.5.3 New post-exposure vaccination regimens 6 3. Diagnosis 7 3.1 Clinical diagnosis 7 3.2 Laboratory diagnosis 7 3.2.1 Postmortem diagnosis of rabies in animals and humans 7 3.2.2 lntra vitam diagnosis of rabies in humans 9 4. Rabies vaccines 4.1 General considerations 4.2 Vaccines for humans 4.2.1 New development in brain-tissue vaccine production 4.2.2 Purified duck-embryo vaccine 4.2.3 Cell-culture vaccines 4.2.4 Potency requirements 4.3 Vaccines for animals 4.3.1 Nerve-tissue vaccines 4.3.2 Cell-culture vaccines 4.3.3 Potency requirements 4.4 Safety 4.4.1 Vaccines for parenteral use 4.4.2 Vaccines for oral immunization of wild and domestic animals 5. Reference materials and virus strains 5.1 lnternational reference preparation of rebies vaccine 5.2 International standard for anti-rabies serum 5.3 Reference reagents for diagnostic purposes 5.4 Seed virus strains 6. Procedures for licensing and release of inactivated tissue-culture vaccines 19 6.1 General considerations 19 6.2 Tests for licensing 20 6.2.1 Vaccines for human use 20 6.2.2 Vaccines for veterinary use 20 6.3 Tests for in-process control 20 6.4 Potency test for batch release

 

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